[4-(propan-2-yloxy)-2-(trifluoromethyl)phenyl]boronic acid
[4-(propan-2-yloxy)-2-(trifluoromethyl)phenyl]boronic acid
CAS: 313545-40-3
Molecular Formula: C10H12BF3O3
[4-(propan-2-yloxy)-2-(trifluoromethyl)phenyl]boronic acid - Names and Identifiers
[4-(propan-2-yloxy)-2-(trifluoromethyl)phenyl]boronic acid - Physico-chemical Properties
| Molecular Formula | C10H12BF3O3 |
| Molar Mass | 248.01 |
| Density | 1.273g/cm3 |
| Boling Point | 333.561°C at 760 mmHg |
| Flash Point | 155.533°C |
| Vapor Presure | 0mmHg at 25°C |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.465 |
[4-(propan-2-yloxy)-2-(trifluoromethyl)phenyl]boronic acid - Introduction
[4-(propan-2-yloxy)-2-(trifluoromethyl)phenyl]boronic acid, also known as [4-(propan-2-yloxy)-2-(trifluoromethyl)phenyl]boronic acid, it is an organic compound.
Nature:
-Appearance: White crystal powder
-Molecular formula: C11H12BF3O3
-Molecular weight: 265.02g/mol
-Melting Point: 110-112 ° C
-Solubility: Soluble in common organic solvents such as ethanol, dimethylformamide (DMF) and dimethyl sulfoxide (DMSO)
Use:
- [4-(propan-2-yloxy)-2-(trifluoromethyl)phenyl]boronic acid is often used as an important reagent in organic synthesis, especially as a substrate or part of a catalyst in Suzuki reactions.
-It can be used to synthesize organic compounds such as drugs, pesticides and chemicals.
-It can also be used to construct compounds containing trifluoromethyl functional groups.
Method:
The preparation of [4-(propan-2-yloxy)-2-(trifluoromethyl)phenyl]boronic acid usually involves a two-step reaction:
1. First, 2-bromo-4-isopropoxybenzene (phosphonium) and trifluoromethylboronic acid (trifluoromethylboronic acid) are reacted by Suzuki in the presence of potassium carbonate or sodium carbonate to obtain the desired product.
2. Then, through appropriate crystal chemistry methods, stable and pure [4-(propan-2-yloxy)-2-(trifluoromethyl)phenyl]boronic acid is obtained.
Safety Information:
-This compound is an organic compound, and you need to pay attention to protective measures when using it.
-May be irritating to eyes, skin and respiratory system, direct contact should be avoided.
-When operating, it should be carried out in a well-ventilated place and wear appropriate personal protective equipment, such as gloves, safety glasses and respiratory protection.
-Avoid contact with oxidants and strong acids during storage and handling to prevent dangerous reactions.
-When using and handling this compound, consult a professional and follow relevant safe use guidelines.
Nature:
-Appearance: White crystal powder
-Molecular formula: C11H12BF3O3
-Molecular weight: 265.02g/mol
-Melting Point: 110-112 ° C
-Solubility: Soluble in common organic solvents such as ethanol, dimethylformamide (DMF) and dimethyl sulfoxide (DMSO)
Use:
- [4-(propan-2-yloxy)-2-(trifluoromethyl)phenyl]boronic acid is often used as an important reagent in organic synthesis, especially as a substrate or part of a catalyst in Suzuki reactions.
-It can be used to synthesize organic compounds such as drugs, pesticides and chemicals.
-It can also be used to construct compounds containing trifluoromethyl functional groups.
Method:
The preparation of [4-(propan-2-yloxy)-2-(trifluoromethyl)phenyl]boronic acid usually involves a two-step reaction:
1. First, 2-bromo-4-isopropoxybenzene (phosphonium) and trifluoromethylboronic acid (trifluoromethylboronic acid) are reacted by Suzuki in the presence of potassium carbonate or sodium carbonate to obtain the desired product.
2. Then, through appropriate crystal chemistry methods, stable and pure [4-(propan-2-yloxy)-2-(trifluoromethyl)phenyl]boronic acid is obtained.
Safety Information:
-This compound is an organic compound, and you need to pay attention to protective measures when using it.
-May be irritating to eyes, skin and respiratory system, direct contact should be avoided.
-When operating, it should be carried out in a well-ventilated place and wear appropriate personal protective equipment, such as gloves, safety glasses and respiratory protection.
-Avoid contact with oxidants and strong acids during storage and handling to prevent dangerous reactions.
-When using and handling this compound, consult a professional and follow relevant safe use guidelines.
Last Update：2024-04-09 19:05:49
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